Haloperidol Drug Class:

Haloperidol is a butyrophenone that belongs to the typical or first-generation antipsychotic drug class. Drugs in this class are primarily used to treat psychotic disorders such as schizophrenia, bipolar disorder, and severe agitation or aggression. They work by blocking certain dopamine (D2) receptors, and minimally, serotonin (5HT2A) receptors in the brain, helping to alleviate symptoms of psychosis and regulate abnormal thought patterns. Healthcare professionals find this drug valuable for treating mental and related illnesses because of its efficacy, safety, and versatility. However, it is not only limited to the realm of psychiatry. Haloperidol is also used in hospice and palliative care, particularly in the management of symptoms in patients at the end of their life.

Haloperidol Doses:

The dosage of haloperidol can vary widely depending on the patient's age, medical condition, and the specific ailment being treated. It is usually administered in tablet, liquid, or injection forms. The typical oral dose for adults with psychiatric disorders is 0.5 to 30 mg per day, divided into smaller doses. In acute situations, higher doses may be necessary. For hospice patients, dosages may be lower and more symptom-specific, typically starting at 0.5 mg once or twice a day.

Uses of Haloperidol:

Haloperidol has several essential uses:

1. Treatment of Psychotic Disorders: Haloperidol is effective in managing symptoms of schizophrenia, bipolar disorder, and other psychotic disorders by reducing hallucinations, delusions, and thought disturbances.

2. Control of Agitation and Aggression: Haloperidol can be used in emergency situations to manage severe agitation or aggression.

3. Nausea and vomiting: Haloperidol is also used to treat chemotherapy-induced nausea and vomiting, especially when other antiemetic medications prove ineffective.

Routes of Administration of Haloperidol:

Haloperidol can be administered through various routes, including oral, intramuscular (IM), and intravenous (IV). The choice of administration route depends on the patient's condition, urgency of treatment, and healthcare provider's preferences. IM and IV routes are often used in acute psychiatric settings or when rapid symptom control is required. In hospice care, oral administration is more common for its convenience and lower invasiveness.

Box Warning:

Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death compared to a placebo.

Side Effects of Haloperidol:

As with any medication, haloperidol can cause side effects, which may include:

1. Extrapyramidal Symptoms (EPS): These include muscle stiffness, restlessness, and involuntary movements.

2. Sedation: Drowsiness and fatigue are common side effects, particularly at higher doses.

3. Weight Gain: Some patients may experience weight gain while taking haloperidol.

4. Cardiac Effects: Prolonged QT intervals may occur, which could lead to arrhythmias.

5. Neuroleptic Malignant Syndrome (NMS): Although rare, NMS is a severe side effect characterized by high fever, muscle rigidity, and altered mental status.

Use of Haloperidol in Hospice Patients:

Hospice care is focused on providing comfort and symptom management for patients who are terminally ill. Haloperidol is sometimes used in hospice settings to address specific symptoms, especially in patients with advanced cancer or other life-limiting conditions. Common applications include:

1. Delirium: Haloperidol can help manage delirium, which often occurs in hospice patients as a result of advanced illness or medication side effects. It may reduce agitation and hallucinations, making the patient more comfortable.

2. Agitation: In some cases, patients nearing the end of life may experience agitation or severe restlessness, which can be distressing for both the patient and their caregivers. Haloperidol can help calm these symptoms, improving the quality of life for the patient.

3. Nausea and Vomiting: Haloperidol's antiemetic properties can be beneficial for hospice patients, particularly those undergoing palliative chemotherapy.

Use of Haloperidol in Hospice Patients at the End of Their Life:

At the end of a patient's life, comfort and quality of life become paramount. Haloperidol may be employed judiciously in hospice care to provide relief from distressing symptoms, improve the patient's comfort, and ensure their dignity during their final moments. It is important that the medication is administered under the guidance of experienced healthcare professionals who can carefully balance its potential benefits and side effects to provide the best possible care for the patient. In this context, haloperidol is a valuable drug in the toolkit of hospice care providers, offering both patients and their families peace of mind during a challenging time.

Fidelis Ariguzo - PharmD, RPH | PDC Rx